Corticosterone differences rather than social housing predict performance of T-maze alternation in male CD-1 mice
Publication Type: |
Journal Article |
Year of Publication: |
2009 |
Authors: |
A.E. Fitchett, C.J. Barnard, H.J. Cassaday |
Publication/Journal: |
Animal Welfare |
Keywords: |
animal welfare, cd-1 mouse, social housing, social rank, t-maze alternation, urinary corticosterone |
Abstract:
This study examined the effects of social housing manipulations on bodyweight, corticosterone levels, and performance of T-maze
alternation in male CD-1 mice. Males that adopted a dominant social rank were heavier than those that adopted a subordinate
social rank. Dominant males also had lower corticosterone concentrations than the subordinates. However, there was little to
suggest that these physiological indicators of social rank were moderated by housing condition. Indeed, statistical analysis
confirmed that the difference in bodyweights was evident before males were socially housed. The mice showed high levels of
spatial alternation on the T-maze from the start of testing so performance accuracy was high. Neither social rank nor housing
condition had any clear categorical effect on T-maze performance. However, performance did fluctuate over successive blocks of
testing and there was a negative association between accuracy on the T-maze and corticosterone levels (consistent with performance
impairment because of elevated corticosterone). Therefore, under present conditions, individual differences in corticosterone
were a better predictor of T-maze performance than social rank or housing condition. The results of the present study lend
further support to the proposition that corticosterone levels measured non-invasively in urine may be used to predict diverse
welfare outcomes for laboratory mice, from bodyweight to cognitive performance. Moreover, intrinsic physiological parameters
rather than external influences, such as social housing, may have more influence on mouse behaviour.