Vitamin A (retinoid) metabolism and actions: What we know and what we need to know about amphibians
Publication Type: |
Journal Article |
Year of Publication: |
2014 |
Authors: |
Robin D. Clugston, William S. Blaner |
Publication/Journal: |
Zoo Biology |
Keywords: |
carotenoid, hypervitaminosis a, retinoic acid, retinol, vitamin a deficiency |
ISBN: |
1098-2361 |
Abstract:
Vitamin A status is an important consideration in the health of both wild and captive amphibians. Data concerning whole body vitamin A homeostasis in amphibians are scarce, although these animals have been used as experimental models to study the actions of vitamin A in vision, limb regeneration and embryogenesis. The available data suggest that many aspects of vitamin A biology in amphibians are similar to the canonical characteristics of vitamin A metabolism and actions established in mammals. This is consistent with the evolutionary conservation of these important biological processes. Amphibians must obtain vitamin A in their diet, with captive animals being prone to vitamin A deficiency. There is still much to be learned about vitamin A biology in amphibians that can only be achieved through rigorous scientific research. Improved understanding of amphibian vitamin A biology will aid the conservation of endangered amphibians in the wild, as well as the successful maintenance of ex situ populations. Zoo Biol. 33:527–535, 2014. © 2014 Wiley Periodicals Inc.