Plasma corticosterone levels in the male iguanid lizard Sceloporus cyanogenys under various physiological conditions
Publication Type: |
Journal Article |
Year of Publication: |
1972 |
Authors: |
D.R. Daugherty, I.P. Callard |
Publication/Journal: |
General and Comparative Endocrinology |
Keywords: |
corticosterone, lizard, sceloporus cyanogenys |
ISBN: |
0016-6480 |
Abstract:
Variations in peripheral plasma corticosterone levels in male iguanid lizards, Sceloporus cyanogenys, were investigated under varying physiological conditions. Control baseline levels of the steroid in plasma were significantly decreased by hypophysectomy, adrenalectomy, hypothalamic lesions, and cyanoketone, an inhibitor of Δ5-3β hydroxysteroid dehydrogenase. Levels were increased following treatment with mammalian ACTH in both intact and hypophysectomized lizards. In the intact animal, ACTH produced a more rapid, more prolonged, and quantitatively greater response of the adrenal gland than the same hormone when administered to the hypophysectomized animal. An apparent increase in corticosterone levels was observed following metyrapone (an 11β-hydroxylase inhibitor) treatment, and aminoglutethimide, an inhibitor of the formation of pregnenolone from cholesterol, had no effect.