Recurrent Long-Lasting Tethering Reduces BDNF Protein Levels in the Dorsal Hippocampus and Frontal Cortex in Pigs

Brain-derived neurotrophic factor (BDNF) signaling has been implicated in the onset of depression and in antidepressant efficacy, although the exact role of this neurotrophin in the pathophysiology of depression remains to be elucidated. Also, the interaction between chronic stress, which may precede depression, corticosteroids and BDNF is not fully understood. The present study aimed at […]