Twenty Years of Research on Cytokine-Induced Sickness Behavior
Cytokine-induced sickness behavior was recognized within a few years of the cloning and expression of interferon-α, IL-1 and IL-2, which occurred around the time that the first issue of Brain, Behavior, and Immunity was published in 1987. Phase I clinical trials established that injection of recombinant cytokines into cancer patients led to a variety of […]
Avoidance of physical activity is a sensitive indicator of illness
Although fever and sickness behavior are common responses to infection, it has been proposed that the sickness behaviors associated with infection, in particular lethargy and fatigue, may be more valuable clinical markers of illness and recovery in patients, than is body temperature alone. Measuring abdominal temperature, food intake and wheel running we therefore determined the […]
Effects of stressors on the behavior and physiology of domestic cats
Feline interstitial cystitis (FIC) is a chronic pain syndrome of domestic cats. Cats with FIC have chronic, recurrent lower urinary tract signs (LUTS) and other comorbid disorders that are exacerbated by stressors. The aim of this study was to evaluate behavioral and physiological responses of healthy cats and cats diagnosed with FIC after exposure to […]
Management and design of hospital pens relative to behavior of the compromised dairy cow: A questionnaire survey of Iowa dairy farms
Compromised dairy cows, such as those suffering from illness or injury, are likely to have different behavioral priorities and needs compared to healthy cows. Although hospital pens are typically required in animal welfare standards and assessment programs, there is surprisingly little information on best practices for housing and management of compromised cows. The purpose of […]