Does the timing of estrogen administration after castration affect its ability to preserve sexual interest in male rats? — Exploring the critical period hypothesis

Abstract Loss of libido is a major side effect that reduces the quality of life of prostate cancer patients on androgen-deprivation therapy. Estrogen restores sexual interest to some extent in castrated male mammals; however, the beneficial effects of estrogen vary greatly among different studies. We investigated whether the timing of estrogen treatment after castration affected […]