Paradoxical sleep deprivation activates hypothalamic nuclei that regulate food intake and stress response

A large body of evidence has shown that prolonged paradoxical sleep deprivation (PSD) results in hypothalamic–pituitary–adrenal (HPA) axis activation, and in loss of body weight despite an apparent increase of food intake, reflecting increased energy expenditure. The flowerpot technique for PSD is an efficient paradigm for investigating the relationships among metabolic regulation and stress response. […]