Physiological and hormonal responses to novelty exposure in rats are mainly related to ongoing behavioral activity

Stress research has been dominated by a circular type of reasoning that occurrence of a stress response is bad. Consequently, the stimulus is often interpreted as stressful in terms of aversiveness involving uncontrollability and unpredictability, which may have maladaptive and pathological consequences. However, the hypothalamic–pituitary–adrenal (HPA) axis and sympathico-adrenomedullary (SAM) system are not only activated […]