“Separation/Abandonment/Isolation Trauma:” What We Can Learn From Our Nonhuman Primate Relatives
Building upon my prior work exploring the impact of childhood abandonment and isolation on chimpanzees and humans, this article discusses the relevance of nonhuman primate research to our understanding of this phenomenon in children. Both laboratory research and naturalistic studies have confirmed the strong commonalities in parenting between our 2 species and have reached similar […]
Maternal separation produces, and a second separation enhances, core temperature and passive behavioral responses in guinea pig pups
During separation in a novel cage, guinea pig pups exhibit passive behavior that appears due to increased proinflammatory activity. To determine if separation also produces a febrile response, the present study used telemetry to provide continuous core temperature measurement of pups exposed to a novel cage for 3 h while either alone or with their […]
Developmental plasticity of HPA and fear responses in rats: A critical review of the maternal mediation hypothesis
Developmental plasticity of HPA and fear responses in rats has been proposed to be mediated by environment-dependent variation in active maternal care. Here, we review this maternal mediation hypothesis based on the postnatal manipulation literature and on our own recent research in rats. We show that developmental plasticity of HPA and fear responses in rats […]
Neonatal maternal separation in male rats increases intestinal permeability and affects behavior after chronic social stress
Prolonged maternal separation in rats has several effects on health and behavior. Here we investigated how maternal separation might interact with social stress in adulthood on behavior and gastrointenstinal permeability. The effects of either daily 180 min long term pup-dam separation (LMS) during the stress hyporesponsive period or daily 10 min brief maternal separation (BMS) […]
Space allowance during gestation and early maternal separation: Effects on the fear response and social motivation of lambs
A common prenatal stressor in lambs is early maternal separation, which may be aggravated by spatial restriction of ewes during pregnancy. They may influence lambs’ development and coping abilities. The aim of this study was to determine how space allowance provided to ewes during pregnancy and early maternal separation affected the fear response and social […]
Involvement of D1 and D2 dopamine receptors in the antidepressant-like effects of selegiline in maternal separation model of mouse
Mother-infant interactions are known to be associated with the psychological well-being of an individual in adulthood. It is well accepted that emotional stress in early life, such as maternal separation (MS), leads to alterations in the neurotransmission systems of various brain regions, especially the mesolimbic dopaminergic system, and subsequently can increase the risk for development […]
Adolescent voluntary exercise attenuated hippocampal innate immunity responses and depressive-like behaviors following maternal separation stress in male rats
Early life stressful events have detrimental effects on the brain and behavior, which are associated with the development of depression. Immune-inflammatory responses have been reported to contribute in the pathophysiology of depression. Many studies have reported on the beneficial effects of exercise against stress. However, underlying mechanisms through which exercise exerts its effects were poorly […]