Neonatal exposure to endocrine active compounds or an ER[beta] agonist increases adult anxiety and aggression in gonadally intact male rats
Endocrine active compounds (EACs) have been shown to influence a number of reproductive endpoints but less is known about how they might affect other hormone dependent behaviors including anxiety and aggression. Recent evidence suggests that these effects may be mediated through the beta form of the estrogen receptor (ER[beta]). Using male Long Evans rats, we […]
Systemic administration of diarylpropionitrile (DPN) or phytoestrogens does not affect anxiety-related behaviors in gonadally intact male rats
The development of highly selective agonists for the two major subforms of the estrogen receptor (ER[alpha] and ER[beta]) has produced new experimental methodologies for delineating the distinct functional role each plays in neurobehavioral biology. It has also been suggested that these compounds might have the potential to treat estrogen influenced behavioral disorders, such as anxiety […]
Neonatal agonism of ER[beta] impairs male reproductive behavior and attractiveness
The organization of the developing male rodent brain is profoundly influenced by endogenous steroids, most notably estrogen. This process may be disrupted by estrogenic endocrine disrupting compounds (EDCs) resulting in altered sex behavior and the capacity to attract a mate in adulthood. To better understand the relative role each estrogen receptor (ER) subtype (ER[alpha] and […]