Twenty Years of Research on Cytokine-Induced Sickness Behavior
Cytokine-induced sickness behavior was recognized within a few years of the cloning and expression of interferon-α, IL-1 and IL-2, which occurred around the time that the first issue of Brain, Behavior, and Immunity was published in 1987. Phase I clinical trials established that injection of recombinant cytokines into cancer patients led to a variety of […]
Behaviour and welfare in relation to pathology
Behaviour is an important way of adapting to disease for individuals and selective pressures resulting from disease have had major consequences for the evolution of behaviour. Behaviour, adrenal and other physiological responses, immunological responses and brain activity all help in coping with disease. Health is an important part of welfare and any pathology implies some […]
The development of a non-invasive behavioral model of thermal heat stress in laboratory mice (Mus musculus)
Background: Many behavioral and physiological studies of laboratory mice employ invasive methods such as radio telemetry to measure key aspects of behavior and physiology. Radio telemetry requires surgical implants, which may impact mouse health and behavior, and thus reduce the reliability of the data collected. New method: We developed a method to measure key aspects […]