Maternal separation produces, and a second separation enhances, core temperature and passive behavioral responses in guinea pig pups
During separation in a novel cage, guinea pig pups exhibit passive behavior that appears due to increased proinflammatory activity. To determine if separation also produces a febrile response, the present study used telemetry to provide continuous core temperature measurement of pups exposed to a novel cage for 3 h while either alone or with their […]
Experimental and husbandry procedures as potential modifiers of the results of phenotyping tests
To maximize the sensitivity of detecting affects of genetic variants in mice, variables have been minimized through the use of inbred mouse lines, by eliminating infectious organisms and controlling environmental variables. However, the impact of standard animal husbandry and experimental procedures on the validity of experimental data is under appreciated. In this study we monitored […]