Oxytocin is increasingly recognized to have a role in human-dog bonding and interactions and a positive influence on various health outcomes including cardiovascular function and stress reactivity. This review summarizes current research investigating human-dog interactions and endogenous oxytocin to highlight the potentially beneficial role of oxytocin within human-dog relationships and overall human health. We discuss progress and challenges for the field, including the assessment of endogenous oxytocin concentrations, and recommend avenues for future research.