The interplay between replacement, reduction and refinement: considerations where the Three Rs interact

Russell and Burch’s Three Rs principle of replacement, reduction and refinement offers a useful concept for the scientific and ethical evaluation of the use of animals in scientific procedures. Replacement, reduction and refinement are often considered separately, but when applied, one of the Three Rs may have a positive or negative effect on one or […]

Effective searching of the scientific literature for alternatives- search grids for appropriate databases.

Researchers searching for alternatives to painful procedures that involve animals may find that the dispersed relevant literature and the array of databases make the search challenging and even onerous. This paper addresses a significant gap that exists for researchers, in identifying appropriate databases to use when searching for specific types of information on alternatives. To […]

Ethics and welfare of animals used in education

Ethical, regulatory and scientific issues arise from the use of animals in education, from secondary level schooling through to veterinary and medical training. A utilitarian cost–benefit analysis can be used to assess whether animals should be used in scientific education. The ‘benefit’ aspect of this analysis can be examined through comparative studies of learning outcomes […]