The prevalence of osteoarthritis in wild versus captive great ape skeletons

This research examined whether the prevalence and skeletal distribution of osteoarthritis (OA) differed between wild and captive great ape skeletons. A secondary, but important, aspect of this research focused on the development of improved aging techniques based on methods commonly used on human osteological samples. Tests were conducted pertaining to the effect that wild versus […]

Terminal investment and senescence in rhesus macaques (Macaca mulatta) on Cayo Santiago

Long-lived iteroparous species often show aging-related changes in reproduction that may be explained by 2 non-mutually exclusive hypotheses. The terminal investment hypothesis predicts increased female reproductive effort toward the end of the life span, as individuals have little to gain by reserving effort for the future. The senescence hypothesis predicts decreased female reproductive output toward […]

A brief overview of chimpanzees and aging research

The Great Ape Aging Project: Caring for and Learning from Apes

The Great Ape Aging Project was initiated to promote improvements in the care and well-being of elderly apes and to advance fundamental knowledge regarding normal aging and age-related disorders. Increased understanding of ape biology and aging in apes can benefit individual apes, apes in general, as well as humans. The project involves behavioral, cognitive, locomotor, […]

Assessment of spontaneously occurring periodic limb movements in sleep in the rat

OBJECTIVE: Periodic limb movements in sleep (PLMS) are often associated with the restless legs syndrome (RLS). Although the dopaminergic system seems to be involved, the pathophysiology of PLMS and RLS is still obscure. The objective of this study is to explore whether a PLMS-like phenomenon can be observed in rodents in order to elucidate the […]

Assessment of reproductive behavior and hormonal cycles in geriatric western Lowland gorillas

Abstract 10.1002/zoo.20124.abs The population of western lowland gorillas in North American zoos is aging and, as is the case with the aging human population, may have unique physical and social needs. We have documented previously that 25% of aging females (5/22) ceased to show reproductive cycles entirely, and could be defined as menopausal. Approximately 32% […]

Evolution of aging: Theoretical and practical implications from rattlesnakes

Abstract 10.1002/(SICI)1098-2361(1996)15:33.3.CO;2-2 Many reptiles live relatively long lives wherein senescence is postponed to an advanced age. Altering nutrition, reproduction, temperature, and other physiological parameters may favorably contribute to increased life spans. But life spans are also evolved characteristics of populations, and the distinctive longevities also result from selective regimes arising within particular environments. Aging is […]

Aging in snakes: Results of long-term captivity on rattlesnake (Crotalus viridis oreganus) predatory behavior

Conservation, scientific study, rehabilitation, and public education concerning animals often require or take advantage of captive individuals. The long-term effects of captivity may affect the success and strategies used in such programs. For reptiles in particular, little is known about the effects of long-term captivity. We compared the predatory behavior of the same eight Northern […]

Heterogeneity of neuroendocrine stress responses in aging rat strains

Hyperactivity of the hypothalamo-pituitary-adrenocortical (HPA) axis is linked with age-related decrements in cognition and neuronal survival. However, the nature and extent of age-related HPA axis deficits vary considerably across and indeed, within strains. The current study was designed to assess variance in HPA axis function using two rodent models commonly used in aging studies: Fischer […]

Aging-related changes in the effects of social isolation on social behavior in rats

Aging is generally associated with cognitive dysfunction and alterations in emotional response. Moreover, in social situations, aging decreases social interaction with unfamiliar individuals, suggesting the decline of social cognition/motivation and a high level of anxiety. Although it is known that isolation housing has various effects on subsequent behavior, including social interaction depending on the age […]